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Related Experiment Videos

Life, death and Sonic hedgehog.

J M Britto1, D Tannahill, R J Keynes

  • 1Department of Anatomy, University of Cambridge, UK.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|June 8, 2000
PubMed
Summary

Sonic hedgehog (SHH) is crucial for embryonic development, not only for tissue polarity but also for cell survival and proliferation. This protein acts as a vital trophic and mitogenic factor during brain development.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Neuroscience

Background:

  • Sonic hedgehog (SHH) is a secreted glycoprotein vital for embryonic development.
  • SHH is a vertebrate homologue of the Drosophila segment polarity gene Hedgehog.
  • Previous studies focused on SHH's role in specifying dorsoventral polarity in neural tubes and somites.

Purpose of the Study:

  • To investigate potential additional functions of SHH beyond dorsoventral specification.
  • To explore SHH's role in cell survival and proliferation during embryogenesis.

Main Methods:

  • Perturbation of SHH signaling in the cranial neural tube.
  • Observation of cell death and proliferation in neural tube and neural crest cells.

Main Results:

  • Perturbing SHH signaling post-dorsoventral specification increased cell death.
  • Increased cell death was observed in both the neural tube and neural crest.
  • Suggests SHH is continuously required for brain development.

Conclusions:

  • SHH signaling is essential for maintaining cell survival and proliferation in the developing brain.
  • SHH functions as a trophic and/or mitogenic factor during brain development.
  • Expands the known cellular responses to SHH signaling in embryogenesis.

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