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Updated: Aug 9, 2026
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The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
Published on: November 26, 2015
An animal model based on the Sprague Dawley rat for the evaluation of ototoxicity
A Martini1, S Hatzopoulos, R Rubini
1Department of ENT, Audiology, University of Ferrara, Italy. mma@dns.unife.it
Annals of the New York Academy of Sciences
|June 8, 2000
Abstract:
Various methodological approaches that can be used to detect ototoxic effects caused by the administration of various substances are presented, using the Sprague-Dawley rat as an animal model. Electrophysiological data are also presented to show how the model behaves with potentially ototoxic (hyaluronic acid) and initially inert (hydroxy-propyl-methyl-cellulose) substances.
