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Keratoconus and mitral valve prolapse.

H Lichter1, N Loya, A Sagie

  • 1Department of Ophthalmology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel. lichterh@netvision.net.il

American Journal of Ophthalmology
|June 14, 2000
PubMed
Summary
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Mitral valve prolapse (MVP) patients show a higher prevalence of keratoconus, a corneal condition. Allergy prevalence was also significantly higher in MVP patients, suggesting a potential link.

Area of Science:

  • Ophthalmology
  • Cardiology
  • Genetics

Background:

  • Mitral valve prolapse (MVP) is a common cardiac condition.
  • Keratoconus is a progressive eye disorder affecting corneal shape.
  • The association between MVP and ocular conditions is an area of ongoing research.

Purpose of the Study:

  • To determine the prevalence of keratoconus in individuals diagnosed with mitral valve prolapse (MVP).
  • To explore potential correlations between MVP and specific clinical findings like allergy and joint hypermobility.

Main Methods:

  • Videokeratography was used to examine 72 eyes of 36 patients with MVP.
  • A control group of 25 individuals was included for comparison.
  • Participants underwent slit-lamp examinations and completed questionnaires on joint hypermobility, arthralgia, asthma, and allergies.

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Main Results:

  • Keratoconus was identified in 22.2% of MVP patients (8 eyes) compared to 4% in controls (1 eye).
  • The MVP group exhibited a significantly higher incidence of conjunctival papillae (P =.015).
  • A statistically significant difference in allergic reaction prevalence was observed between groups (P =.001).

Conclusions:

  • A potential association exists between mitral valve prolapse (MVP) and keratoconus.
  • The study suggests that patients with MVP experiencing vision problems should be evaluated for keratoconus.
  • Allergy appears to be more prevalent in individuals with MVP.