Related Experiment Video

Updated: Jul 29, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

[Grand prematurity, risk of neuropsychic handicaps and neuroprotection]

S Marret1, L Marpeau

  • 1Clinique de Pédiatrie et de Puériculture, Service de Médecine Néonatale, Hôpital Charles-Nicolle, Rouen.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|June 9, 2000
PubMed

Insights

Preterm infants face high risks of cerebral palsy and neurodevelopmental issues. New strategies focus on preventing brain lesions through infection control and neuroprotection.

Area of Science:

  • Neonatal neurology
  • Developmental neurobiology
  • Neuroepidemiology

Context:

  • While survival rates for very and extremely preterm infants have improved, they remain vulnerable to significant neurodevelopmental challenges.
  • Cerebral palsy, neuromotor dysfunction, and cognitive impairments are prevalent risks in this population.
  • Periventricular white matter lesions (hemorrhagic or necrotic) pose a critical threat to the developing preterm brain.

Purpose:

  • To explore the multifactorial pathophysiology of brain lesions in preterm infants.
  • To highlight the importance of early infection detection and management.
  • To introduce novel neuroprotective strategies for preventing cerebral palsy.

Summary:

  • Improved survival of preterm infants does not negate the risk of neurodevelopmental sequelae, particularly cerebral palsy.
  • Brain lesions in the periventricular white matter are a primary concern for developing brains of preterm neonates.
  • Advances in neuroimaging, neurobiology, and epidemiology enable a deeper understanding of brain lesion development.

Impact:

  • Early detection and treatment of infections are crucial for preventing brain injury.
  • Neuroprotective agents targeting excitotoxicity, free radicals, and inflammation offer promising avenues for cerebral palsy prevention.
  • This research informs strategies to mitigate long-term neurological deficits in preterm survivors.

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

Related Concept Videos

Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Intellectual Disability01:29

Intellectual Disability

Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...