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Differential behavior of coagulation factor XIII in patients with inflammatory bowel disease and in patients with

A A Vrij1, J Rijken, J W van Wersch

  • 1Department of Gastroenterology, University Hospital Maastricht, The Netherlands. tvr@sint.azm.nl

Haemostasis
|June 9, 2000
PubMed

Insights

Low coagulation factor XIII (FXIII) activity characterizes active inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Serial FXIII measurements may help monitor IBD disease activity.

Area of Science:

  • Hematology
  • Gastroenterology
  • Rheumatology

Background:

  • Coagulation factor XIII (FXIII) plays a role in hemostasis.
  • Inflammatory bowel disease (IBD) and giant cell arteritis (GCA) are inflammatory conditions with potential hemostatic alterations.

Purpose of the Study:

  • To investigate the association between FXIII activity and disease activity in IBD (Crohn's disease [CD] and ulcerative colitis [UC]) and GCA.
  • To compare FXIII levels in patients with active disease versus inactive disease and healthy controls.

Main Methods:

  • Prospective study measuring plasma FXIII activity in newly diagnosed CD, UC, and GCA patients during active and inactive phases.
  • Serial measurements were taken at 3-month intervals over a median follow-up of 12 months.
  • Comparison with age- and sex-matched noninflammatory control groups for IBD and GCA.

Main Results:

  • FXIII activity was significantly lower in active CD and UC compared to active GCA and noninflammatory controls.
  • In CD and UC, FXIII activity showed an inverse correlation with clinical disease activity indices, erythrocyte sedimentation rate, fibrinogen, and C-reactive protein.
  • Low FXIII activity was identified as a characteristic feature of active IBD.

Conclusions:

  • Low FXIII activity is a hallmark of active IBD (CD and UC).
  • Serial FXIII measurements could serve as a valuable tool for assessing and monitoring IBD disease activity.
  • Further research may elucidate the precise mechanisms linking FXIII to IBD pathogenesis and activity.

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