Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic exercise training does not alter pulmonary vasorelaxation in normal pigs.

L R Johnson1, M H Laughlin

  • 1Department of Veterinary Biomedical Sciences, University of Missouri, Columbia 65211, USA. JohnsonLR@missouri.edu

Journal of Applied Physiology (Bethesda, Md. : 1985)
|June 14, 2000
PubMed
Summary

Chronic exercise training did not enhance pulmonary artery vasorelaxation in normal pigs. This study found no significant differences in endothelium-dependent or independent relaxation after 16 weeks of treadmill exercise.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Scedosporium spp.</i> rhinitis in 4 dogs from Northern California.

Medical mycology case reports·2026
Same author

Medicolegal autopsies in private medical colleges in India: An urgent need.

Journal of postgraduate medicine·2022
Same author

A Mathematical Modeling Approach to the Cort-Fitness Hypothesis.

Integrative organismal biology (Oxford, England)·2021
Same author

Age influences the thermal suitability of <i>Plasmodium falciparum</i> transmission in the Asian malaria vector <i>Anopheles stephensi</i>.

Proceedings. Biological sciences·2020
Same author

Comparison of fluoroscopic cardiovascular measurements from healthy dogs obtained at end-diastole and end-systole.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2020
Same author

Localization of Contextual and Context Removed Auditory Fear Memory within the Basolateral Amygdala Complex.

Neuroscience·2018

Area of Science:

  • Cardiovascular Physiology
  • Exercise Science
  • Pulmonary Circulation

Background:

  • Exercise training is known to improve vascular function.
  • Previous studies suggest exercise enhances acetylcholine-induced pulmonary vasorelaxation in pigs with coronary occlusion.
  • The effect of exercise on pulmonary artery vasorelaxation in healthy pigs remains less understood.

Purpose of the Study:

  • To investigate the impact of chronic exercise training on endothelium-dependent and endothelium-independent vasorelaxation in pulmonary arteries of normal pigs.
  • To determine if exercise training alters the responsiveness of pulmonary arteries to acetylcholine and sodium nitroprusside.

Main Methods:

  • Yucatan miniswine were subjected to 16 weeks of treadmill exercise (Ex) or remained sedentary (Sed).

Related Experiment Videos

  • Isometric techniques were used to assess contractile responses to KCl and norepinephrine (NE).
  • Endothelium-dependent relaxation to acetylcholine (ACh) and endothelium-independent relaxation to sodium nitroprusside were measured, with and without nitric oxide synthase and cyclooxygenase inhibition, and endothelial denudation.

    • Main Results:

    • Pulmonary arteries from exercised pigs showed increased contraction to 80 mM KCl, but norepinephrine responses were similar between groups.
    • No significant differences in endothelium-dependent relaxation to ACh were observed between sedentary and exercised pigs.
    • Endothelium-independent relaxation to sodium nitroprusside also did not differ between the groups, even with pharmacological inhibition or denudation.

    Conclusions:

    • Chronic exercise training for 16 weeks does not alter endothelium-dependent vasorelaxation in pulmonary arteries of normal pigs.
    • Exercise training does not affect endothelium-independent vasorelaxation in the pulmonary arteries of normal pigs.
    • These findings suggest that the benefits of exercise on pulmonary vascular function may be context-dependent, potentially differing in the presence of disease states.