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Updated: Jul 18, 2026

Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
Published on: November 24, 2014
[Function improvement in levography following aortocoronary bypass].
Coronary artery surgery can restore heart function in patients with severe left ventricular impairment caused by reversible ischemia. This improvement was observed even in patients with minimal or no angina pectoris symptoms.
Area of Science:
- Cardiology
- Cardiac Surgery
- Myocardial Ischemia
Background:
- Coronary artery disease (CAD) can lead to severe left ventricular dysfunction.
- Myocardial ischemia may impair cardiac function even without overt angina pectoris.
- The reversibility of myocardial dysfunction is key to surgical outcomes.
Purpose of the Study:
- To investigate the potential for functional recovery of akinetic myocardial segments after aortocoronary bypass surgery.
- To identify clinical predictors of improved cardiac function post-surgery in CAD patients.
- To evaluate the efficacy of coronary artery surgery in patients with severe left ventricular dysfunction due to ischemia.
Main Methods:
- Prospective evaluation of 63 patients 6-12 months post-aortocoronary surgery using coronary angiography.
- Assessment of left ventricular ejection fraction (LVEF) pre- and post-surgery.
- Analysis of clinical parameters including angina pectoris and electrocardiogram (ECG) findings.
Main Results:
- Actively contracting segments were observed in 8 of 63 patients (12.7%) with previously akinetic areas.
- Mean ejection fraction significantly increased from 48.1% to 68.3% post-surgery.
- Preoperative predictors included rest angina and a discrepancy between severe ventriculographic and mild ECG findings.
Conclusions:
- Severe left ventricular dysfunction in CAD is not an absolute contraindication for coronary artery surgery if ischemia is reversible.
- Myocardial function can improve significantly post-surgery, even in patients with minimal angina.
- Coronary artery surgery is effective in restoring function to ischemic but viable myocardium.
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