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Determination of urate crystal formation using flow cytometry and microarea X-ray diffractometry.

K Kaneko1, M Maru

  • 1Central Laboratory of Analytical Biochemistry, School of Medicine, Teikyo University, Tokyo, Japan.

Analytical Biochemistry
|June 10, 2000
PubMed
Summary

Flow cytometry (FCM) effectively detects early monosodium urate (MSU) crystal formation, crucial for understanding gouty arthritis. This method, enhanced by gamma-globulin and lactic acid, aids in early gout diagnosis.

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Determination of Crystal Structures01:29

Determination of Crystal Structures

In the late 1800s, the revelation that light extended beyond visible wavelengths led to the discovery of X-rays by Wilhelm Roentgen. Recognized as high-energy electromagnetic radiation with short wavelengths, X-rays prompted exploration into their interaction with crystals. Max von Laue proposed in 1912 that the periodic arrangement of atoms, ions, or molecules in crystals would cause them to diffract X-rays, a hypothesis confirmed through experiments with copper sulfate and zinc sulfide...