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Evidence for phosphorylation-dependent conformational changes in methylesterase CheB

G S Anand1, P N Goudreau, J K Lewis

  • 1Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, USA.

Protein Science : a Publication of the Protein Society
|June 13, 2000
PubMed
Summary

Phosphorylation of the CheB response regulator activates its methylesterase activity by inducing conformational changes. These changes reposition regulatory domains, enhancing substrate access and enzyme function.

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