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Aneurysmal bone cyst of the spine with familial incidence
M R DiCaprio1, M J Murphy, R L Camp
1Departments of Orthopaedics and Rehabilitation and Pathology, Yale University School of Medicine, New Haven, CT 06520-8071, USA. dicaprio@javanet.com
Study Design:
A report of two cases of aneurysmal bone cysts of the spine occurring in a father and daughter.
Objective:
To present an unusual finding of familial incidence of aneurysmal bone cyst and review the literature.
Summary Of Background Data:
Aneurysmal bone cysts are benign, expanding, locally aggressive lesions. Up to 20% of cases involve the spine. The cause of primary aneurysmal bone cysts remains unclear. There have been three previous reports of a familial incidence supporting the importance of a hereditary component in the cause of aneurysmal bone cysts.
Methods:
A 36-year-old man and a 7-year-old girl were diagnosed with aneurysmal bone cyst involving the spine by clinical manifestations, radiographic features, and histologic evaluation.
Results:
The father remains recurrence- and symptom-free 6 years after primary resection. Five months after surgery, the daughter was found to have recurrent disease by magnetic resonance imaging and underwent a second procedure within 1 year of the primary resection.
Conclusion:
The occurrence of a primary aneurysmal bone cyst in two family members, occurring at adjacent vertebral levels, is suggestive of a hereditary component to the formation of primary aneurysmal bone cyst.