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Updated: Aug 17, 2026

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
Published on: June 9, 2017
Downregulation of G protein-coupled receptors
1Department of Psychiatry and Cellular and Molecular Pharmacology, Box 0984 IRE, Room LP-A104, University of California, San Francisco, San Francisco, CA 94143-0984, USA.
Abstract:
Major advances have been made in understanding mechanisms mediating downregulation of G protein-coupled receptors. Recent studies emphasize the role of multiple proteolytic mechanisms in downregulation. A specific mechanism of downregulation, mediated by endocytosis of receptors via clathrin-coated pits followed by sorting to lysosomes, has been examined in detail. Specific protein interactions that control the specificity of G-protein-coupled receptor trafficking in this pathway are beginning to be elucidated.
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