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Hippocampal sulcal cavities on MRI: relationship to age and apolipoprotein E genotype
D P Barboriak1, P M Doraiswamy, K R Krishnan
1Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA. barbo013@mc.duke.edu
Neurology
|June 14, 2000
Abstract:
Hippocampal sulcal cavities are usually considered incidental findings on brain MRI. In a group of 92 elderly volunteers, the authors graded the number and size of hippocampal sulcal cavities with brain MRI to obtain a cavity score. Cavity scores increased with age, and were higher in subjects carrying the APOE epsilon4 or epsilon2 alleles than in subjects with the epsilon3/3 genotype. Age-related morphologic changes in the hippocampus may be mediated by the APOE genotype.