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Related Experiment Videos

Status epilepticus associated with cefepime.

S Dixit1, P Kurle, L Buyan-Dent

  • 1Department of Neurology, University of Wisconsin at Madison, 53792-5132, USA.

Neurology
|June 14, 2000
PubMed
Summary
This summary is machine-generated.

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Cefepime, a common antibiotic for gram-negative sepsis, can cause nonconvulsive status epilepticus. This neurological side effect resolved after discontinuing cefepime treatment.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Pharmacology

Background:

  • Cefepime is a broad-spectrum, fourth-generation cephalosporin antibiotic.
  • It is frequently prescribed for severe gram-negative bacterial infections, including sepsis.
  • Pseudomonas aeruginosa infections are a common indication for cefepime therapy.

Observation:

  • Two patients developed nonconvulsive status epilepticus (NCSE).
  • NCSE occurred during treatment with cefepime for Pseudomonas aeruginosa infections.
  • Patients received standard or high doses of cefepime.

Findings:

  • Cefepime therapy was directly linked to the onset of NCSE in both cases.
  • Withdrawal of cefepime led to complete resolution of the status epilepticus.

Related Experiment Videos

  • The risk of NCSE may be dose-dependent.

    • Implications:

    • Clinicians should consider cefepime as a potential cause of NCSE.
    • Neurological monitoring may be warranted in patients receiving cefepime, particularly at higher doses.
    • This finding highlights the importance of recognizing drug-induced neurological adverse events.