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[HELLP syndrome].

K Haram1, L Bjørge, K Guttu

  • 1Kvinneklinikken, Haukeland Sykehus.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|June 14, 2000
PubMed
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HELLP syndrome, a severe pregnancy complication, involves hemolysis, elevated liver enzymes, and low platelets. Early diagnosis and corticosteroid treatment are key for managing this condition, especially in severe preeclampsia cases.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Hematology

Context:

  • HELLP syndrome affects 10-20% of severe preeclampsia cases.
  • It is a serious pregnancy complication with diverse clinical presentations.
  • Pathogenesis involves genetic, immunologic, and coagulation factors.

Purpose:

  • To review the literature on HELLP syndrome.
  • To describe the characteristics, pathogenesis, and management of HELLP syndrome.

Summary:

  • HELLP syndrome (hemolysis, elevated liver enzymes, low platelets) presents variably, sometimes without classic symptoms like hypertension or abdominal pain.
  • Pathogenesis involves placental coagulation imbalance, cytokine production, endothelial dysfunction, and fibrin deposition.
  • Approximately 70% of cases occur pre-delivery, with some presenting in the second trimester or postpartum.

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Impact:

  • Highlights the importance of recognizing atypical HELLP syndrome presentations.
  • Suggests corticosteroid therapy as a beneficial treatment option.
  • Emphasizes timely delivery after clinical stabilization for classic HELLP syndrome.