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Updated: Oct 15, 2026

Tissue Preparation and Immunostaining of Mouse Sensory Nerve Fibers Innervating Skin and Limb Bones
Published on: January 26, 2012
[Histology and elementary pathology of the peripheral nerve]
J M Vallat1, A V Vallat-Decouvelaere
1Service de neurologie CHU Dupuytren, Limoges.
Abstract:
The lesions which give rise to peripheral neuropathy are induced by a variety of mechanisms. Their etiology can often be established from the results of electrophysiological examination and (or) study of nerve biopsy; knowledge of the etiology will guide the treatment strategy. In this chapter, we discuss typical lesional mechanisms including: axonal involvement (Wallerian degeneration, axonopathies) and demyelinating lesions (whether segmental, indicative of an acquired inflammatory process, or of a more extensive nature, indicative of a genetic origin). The indication for nerve biopsy, which enables identification of the lesions, should be considered on a case by case basis.
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