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Structural analogues of some highly active non-competitive AMPA antagonists
T Hámori1, S Sólyom, P Berzsenyi
1Institute for Drug Research, Ltd, Budapest, Hungary.
Bioorganic & Medicinal Chemistry Letters
|June 15, 2000
Abstract:
Some 5-methyl analogues (14a-e) of the non-competitive AMPA antagonists 3-acylated 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-4,5-dihydro-3H-2,3-benzodi azepines (2,3) have been synthesized. Generally they show diminished or low biological activity but two derivatives (14a,b) reveal effects comparable to those of GYKI 52466 (1), the prototype non competitive AMPA antagonist.