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[The search for anti-ulcer agents at IDR]
1Gyógyszerkutató Intézet Kft., 1325 Budapest, Pf. 82.
Acta Pharmaceutica Hungarica
|January 5, 2002
Abstract:
2-Pyridyl-thioacetamide (2-PTA) was synthesized at IDR in 1968. This molecule showed strong antiulcer/antisecretory effects in animals and man by inhibiting the proton pump. Based on our work Astra developed omeprazole which is the No. 1 drug in the world from 1996. 2-PTA remained a very popular template for drug design for a quarter of century.