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Murine Model of CD40-activation of B cells
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The role of CD40-CD154 interactions in the regulation of cell mediated immunity

A Miga1, S Masters, M Gonzalez

  • 1Department of Microbiology, Dartmouth Medical School, Lebanon, NH 03756, USA.

Immunological Investigations
|June 15, 2000
PubMed

CD40 is expressed on a diverse array of cell types from the hematopoietic and non-hematopoietic compartments. Within the hematopoietic compartment, CD40 is found constitutively expressed on B cells, dendritic cells (DC) and macrophages. The function of CD40 in B cells has been documented as being essential in the control of humoral immunity. In DCs and macrophages, CD40 has been shown to be important in the induction of antigen-presenting cell (APC) maturation and effector function. CD40 is also expressed on non-hematopoietic cells like keratinocytes, epithelial cells, and vascular endothelial cells and has been shown to be functionally important on these cell types.

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