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[Piperacillin: use at a general hospital].
E A Nieto1, F S Porta, A M Besolí
1Programa Asistencial de Patología Infecciosa, Corporació Sanitària Parc Taulí, 08208 Sabadell, Barcelona.
Summary
Piperacillin remains a key antibiotic for treating neutropenic infections and nosocomial pneumonia in hospitals. It shows continued effectiveness against Pseudomonas aeruginosa, a common Gram-negative pathogen.
Area of Science:
- Clinical Pharmacy
- Infectious Diseases
- Antimicrobial Stewardship
Context:
- Piperacillin is a widely used beta-lactam antibiotic.
- Antimicrobial resistance necessitates ongoing analysis of antibiotic use.
- Understanding treatment patterns is crucial for effective hospital-acquired infection management.
Purpose:
- To retrospectively analyze the utilization patterns and clinical indications of piperacillin.
- To evaluate the efficacy of piperacillin, particularly in combination therapy.
- To assess treatment outcomes and mortality associated with piperacillin use in a general hospital setting.
Summary:
- A retrospective analysis of 385 infectious episodes in 338 patients treated with piperacillin between 1996-1997 was conducted.
- Key indications included neutropenic infections (39.2%) and nosocomial infections, often treated with piperacillin and aminoglycoside combinations (86.2%).
- Gram-negative bacilli, including Pseudomonas aeruginosa, were frequently isolated, with piperacillin demonstrating good activity.
Impact:
- Piperacillin continues to be a valuable therapeutic option for specific infections, especially in neutropenic patients and for nosocomial pneumonia.
- The study highlights the sustained clinical relevance of piperacillin in general hospital practice.
- Findings support the continued use of piperacillin for infections caused by susceptible pathogens like Pseudomonas aeruginosa.