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Related Experiment Videos

Chloroquine induced parkinsonism.

R C Parmar1, C V Valvi, J R Kamat

  • 1Department of Paediatrics, Seth G. S. Medical College and K. E. M. Hospital, Parel, Mumbai - 400 012, India.

Journal of Postgraduate Medicine
|June 16, 2000
PubMed
Summary
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A child developed parkinsonism after prolonged chloroquine use. Symptoms resolved after discontinuing the drug and initiating treatment, showing reversible toxic effects.

Area of Science:

  • Pediatric Neurology
  • Toxicology
  • Pharmacology

Background:

  • Chloroquine is an antimalarial and antirheumatic drug.
  • Drug-induced parkinsonism is a known, though uncommon, side effect.
  • Pediatric cases of drug toxicity require careful monitoring and management.

Observation:

  • A 5-year-old male presented with symptoms of parkinsonism, including bradykinesia, hypomimia, and a parkinsonian gait.
  • The child had a history of prolonged chloroquine administration.
  • Neurological examination revealed no tremors, and investigations (CT scan, CSF, ceruloplasmin) were unremarkable.

Findings:

  • The patient's parkinsonian symptoms were directly linked to chloroquine exposure.
  • Discontinuation of chloroquine and initiation of trihexyphenidyl led to symptom improvement.

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  • The observed toxic manifestations were transient and fully reversible.

    • Implications:

    • This case highlights the potential for chloroquine to induce parkinsonism in children.
    • Early recognition and drug withdrawal are crucial for managing chloroquine-induced parkinsonism.
    • This case underscores the importance of considering medication side effects in pediatric movement disorders.