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Sphingolipid transport in eukaryotic cells.

G van Meer1, J C Holthuis

  • 1Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands. g.vanmeer@amc.uva.nl

Biochimica Et Biophysica Acta
|June 17, 2000
PubMed
Summary
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Sphingolipids are vital eukaryotic membrane lipids. This review explores how proteins controlling sphingolipid synthesis, breakdown, and transport regulate their cellular concentration and functions.

Area of Science:

  • Cell Biology
  • Biochemistry
  • Membrane Biology

Background:

  • Sphingolipids are essential membrane components in eukaryotes.
  • They play key roles in membrane organization, cell signaling, and cell interactions.
  • Sphingolipid-derived molecules act as second messengers.

Purpose of the Study:

  • To review the intricate control of sphingolipid intracellular topology.
  • To highlight the role of proteins in regulating sphingolipid concentration and function.

Main Methods:

  • Literature review of sphingolipid metabolism and function.
  • Analysis of protein-mediated regulation of sphingolipid transport and homeostasis.

Main Results:

  • Sphingolipids are crucial for membrane domain organization, protein sorting, and signaling.

Related Experiment Videos

  • Glycosphingolipids mediate cell recognition, differentiation, and interactions.
  • Sphingolipid metabolism generates second messengers impacting cellular homeostasis.

    • Conclusions:

    • Protein-mediated regulation of sphingolipid synthesis, hydrolysis, and transport is critical.
    • Precise control of sphingolipid local concentration dictates their diverse cellular roles.
    • Understanding sphingolipid topology is key to comprehending eukaryotic cell function.