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Developmental instability and schizotypy.

A Rosa1, J van Os, L Fañanás

  • 1Laboratori d'Antropologia, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028, Barcelona, Spain.

Schizophrenia Research
|June 20, 2000
PubMed
Summary
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Negative schizotypy in adolescents is linked to developmental instability, indicated by fluctuating asymmetry (FA). This association, more pronounced in boys, suggests early developmental disruptions may influence psychosis proneness.

Area of Science:

  • Developmental Psychology
  • Psychopathology
  • Behavioral Genetics

Background:

  • Developmental stability (DS) is crucial for normal cognitive and lateralization development.
  • Fluctuating asymmetry (FA), a measure of developmental instability, may reflect deviations from the ontogenic program.
  • Schizophrenia research suggests a link between developmental disturbances and schizotypy dimensions.

Purpose of the Study:

  • To investigate the relationship between fluctuating asymmetry (FA) and dimensions of schizotypy in healthy adolescents.
  • To explore whether FA is associated with cognitive function and laterality measures in relation to schizotypy.
  • To determine if FA is a more sensitive indicator of schizotypy phenotype than laterality measures.

Main Methods:

  • Examined associations between FA (a-b ridge count asymmetry), cognitive ability, and laterality in 260 healthy adolescents (ages 11.9-15.6).

Related Experiment Videos

  • Utilized neuropsychological tests for general cognitive ability and frontal function.
  • Assessed laterality using the Annett scale.

    • Main Results:

    • Negative schizotypy showed a dose-response association with increased FA and lower general cognitive ability.
    • This association between negative schizotypy and FA was more evident in adolescent boys.
    • No significant associations were found between schizotypy dimensions and laterality or frontal function.

    Conclusions:

    • Early developmental instability, as indicated by FA, may be associated with the negative dimension of schizotypy.
    • FA appears to be a more sensitive marker for the schizotypy phenotype compared to laterality measures.
    • Findings suggest developmental instability may underlie aspects of schizotypy, mirroring patterns observed in schizophrenia.