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[Role of CDC25 phosphatases in the control of proliferation]
N Davezac1, B Ducommun, V Baldin
1Laboratoire de biologie cellulaire et moléculaire du contrôle de la prolifération, université Paul-Sabatier, CNRS UMR 5088, Toulouse, France.
Pathologie-Biologie
|June 20, 2000
Abstract:
Progression in cell cycle is controlled by CDKs (cyclin dependent kinases) and their cyclins regulatory subunits. In mammalian cells, three dual specificity phosphatases called CDC25 activate CDKs/cyclin complexes. The activity of CDC25 is regulated by phosphorylation and dephosphorylation events. CDC25 phosphatases also participate in cell cycle checkpoints activated in response to DNA damage. Two members of this family, CDC25 A and CDC25 B, have oncogenic properties, and their overexpression has been detected in various types of tumors.