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Updated: Oct 19, 2025

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
Published on: July 27, 2018
Healthy Aging Biomarkers: The INSPIRE's Contribution
I Ader1, L Pénicaud, S Andrieu
1Louis Casteilla, RESTORE, UMR 1301-Inserm 5070 Etablissement Français du Sang-Occitanie (EFS), Inserm 1031, University of Toulouse III, National Veterinary School of Toulouse (ENVT), CNRS, Toulouse, France; louis.casteilla@inserm.fr.
Abstract:
The find solutions for optimizing healthy aging and increase health span is one of the main challenges for our society. A novel healthcare model based on integration and a shift on research and care towards the maintenance of optimal functional levels are now seen as priorities by the WHO. To address this issue, an integrative global strategy mixing longitudinal and experimental cohorts with an innovative transverse understanding of physiological functioning is missing. While the current approach to the biology of aging is mainly focused on parenchymal cells, we propose that age-related loss of function is largely determined by three elements which constitute the general ground supporting the different specific parenchyma: i.e. the stroma, the immune system and metabolism. Such strategy that is implemented in INSPIRE projects can strongly help to find a composite biomarker capable of predicting changes in capacity across the life course with thresholds signalling frailty and care dependence.
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