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Mass spectrometry for genotyping: an emerging tool for molecular medicine
P E Jackson1, P F Scholl, J D Groopman
1Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA. pjackson@jhsph.edu
Molecular Medicine Today
|June 22, 2000
Abstract:
Recent technological innovations have made proteins and nucleic acids accessible to mass spectrometric analysis. As a result of their inherently high specificity, accuracy and throughput, there is considerable interest in developing mass spectrometric methods for genotype analysis in clinical diagnostic and research applications. This review outlines some of the most promising genotyping methods developed using electrospray and matrix-assisted laser-desorption-ionization mass spectrometry.