Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methodological issues in randomized controlled trials.

R Morley1, V Farewell

  • 1Menzies Centre for Population Health Research, Tasmania, Australia.

Seminars in Neonatology : SN
|June 22, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of Topical Vancomycin- and Gentamicin-Loaded Calcium Sulfate Beads or Systemic Antibiotics in Eradicating Polymicrobial Biofilms Isolated from Diabetic Foot Infections within an <i>In Vitro</i> Wound Model.

Antimicrobial agents and chemotherapy·2021
Same author

Pulmonary Metastasectomy in Colorectal Cancer: updated analysis of 93 randomized patients - control survival is much better than previously assumed.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2020
Same author

Adapting the James Lind Alliance priority setting process to better support patient participation: an example from cystic fibrosis.

Research involvement and engagement·2019
Same author

Top research priorities in healthcare-associated infection in the UK.

The Journal of hospital infection·2019
Same author

Do drugs offering only PFS maintain quality of life sufficiently from a patient's perspective? Results from AVALPROFS (Assessing the 'VALue' to patients of PROgression Free Survival) study.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2018
Same author

Wilm's Tumor: An Update.

Cancer·2018
Same journal

Role of micro-organisms in necrotizing enterocolitis.

Seminars in neonatology : SN·2020
Same journal

The epidemiology and pathogenesis of necrotizing enterocolitis.

Seminars in neonatology : SN·2020
Same journal

Regionalized perinatal education.

Seminars in neonatology : SN·2005
Same journal

Regional quality assessment in perinatal care.

Seminars in neonatology : SN·2005
Same journal

Regionalized long-term follow-up.

Seminars in neonatology : SN·2005
Same journal

Regionalized neonatal emergency transport.

Seminars in neonatology : SN·2005
See all related articles

Conducting rigorous randomized controlled trials is crucial for evidence-based medicine. Proper design and methodology ensure reliable results, avoiding wasted resources and ethical concerns in clinical research.

Area of Science:

  • Clinical Trials Methodology
  • Evidence-Based Medicine
  • Research Ethics

Background:

  • Increasing emphasis on evidence-based medicine necessitates high-quality research.
  • Randomized controlled trials (RCTs) are the gold standard for generating robust evidence.
  • Methodological rigor is paramount for the validity and reliability of clinical trial outcomes.

Purpose of the Study:

  • To highlight general methodological issues in randomized controlled trials.
  • To discuss special considerations for trials requiring long-term follow-up.
  • To underscore the ethical imperative of well-designed and well-conducted clinical studies.

Main Methods:

  • Focus on general methodological principles applicable to all clinical trials.
  • Discussion of specific challenges related to long-term follow-up in RCTs.

Related Experiment Videos

  • Selection of topics based on authors' experience and expertise in trial design.

    • Main Results:

    • Methodological weaknesses, including inappropriate design or sample size, can render study results unreliable.
    • Poor outcome measurement or high subject loss can compromise even well-designed trials.
    • The principles of good trial design are essential for both short-term and long-term outcome studies.

    Conclusions:

    • Well-designed and well-conducted randomized controlled trials are fundamental to evidence-based medicine.
    • Methodological flaws in clinical trials lead to wasted resources and raise ethical concerns.
    • Adherence to sound methodological practices is critical for the integrity of clinical research.