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Dietary caffeine intake and the risk for detrusor instability: a case-control study
L A Arya1, D L Myers, N D Jackson
1Division of Urogynecology, Department of Obstetrics and Gynecology, Brown University School of Medicine, Providence, RI 02905, USA. larya@wihri.org
Obstetrics and Gynecology
|June 23, 2000
Summary
High caffeine intake is associated with an increased risk of detrusor instability in women. Further research is needed to confirm if this link is causal.
Area of Science:
- Urology
- Nephrology
- Epidemiology
Background:
- Detrusor instability is a common condition affecting women's urinary health.
- Caffeine is a widely consumed stimulant with potential effects on bladder function.
Purpose of the Study:
- To investigate the association between caffeine consumption and the risk of developing detrusor instability in women.
- To quantify the relationship between different levels of caffeine intake and detrusor instability.
Main Methods:
- A case-control study involving 131 women with detrusor instability and 128 controls.
- Participants completed a 48-hour voiding diary and underwent urodynamic testing.
- Caffeine intake was categorized as minimal (<100 mg/day), moderate (100-400 mg/day), and high (>400 mg/day).
Main Results:
- Women with detrusor instability had significantly higher mean daily caffeine intake (484 mg) compared to controls (194 mg).
- High caffeine intake was a significant risk factor for detrusor instability, even after adjusting for age and smoking (OR 2.4).
- Moderate caffeine intake did not show a statistically significant association with detrusor instability.
Conclusions:
- A significant association exists between high caffeine intake and detrusor instability in the studied population.
- Further large-scale studies are recommended to establish a causal relationship between caffeine and detrusor instability.