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Updated: Jul 28, 2026
15:22
Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Functionalized nucleoside 5'-triphosphates for in vitro selection of new catalytic ribonucleic acids
J Matulic-Adamic1, A T Daniher, A Karpeisky
1Department of Chemistry & Biochemistry, Ribozyme Pharmaceuticals, Inc., Boulder, CO 80301, USA.
Bioorganic & Medicinal Chemistry Letters
|June 24, 2000
Abstract:
A series of novel 2'-modified nucleoside 5'-triphosphates was synthesized. The amino, imidazole, and carboxylate functionalities were attached to the 5-position of pyrimidine base of these molecules through alkynyl and alkyl spacers, respectively. Two different phosphorylation methods were used to optimize the yields of these highly modified triphosphates.
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