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Related Experiment Video

Updated: Jun 16, 2026

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model
07:34

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model

Published on: September 22, 2020

[Endogenous porcine retroviruses and xenotransplantation].

J F Mornex1

  • 1Inra UMR 754, ¿ecole nationale v¿et¿erinaire de Lyon et universit¿e Claude-Bernard Lyon 1, France.

Pathologie-Biologie
|June 27, 2000
PubMed
Summary
This summary is machine-generated.

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Veterinary immunology and immunopathology·2005

Porcine endogenous retroviruses (PERVs) can cross species barriers and infect human cells in vitro. Their use in xenotransplantation poses a potential risk for novel retroviral adaptation in humans, requiring careful recipient monitoring.

Area of Science:

  • Virology
  • Genomics
  • Immunology

Context:

  • Vertebrate DNA harbors endogenous retroviruses (ERVs), distinct from pathogenic retroviruses.
  • Porcine endogenous retroviruses (PERVs) were identified in 1974 and are expressed in cells relevant to transplantation.
  • ERVs, including PERVs, possess the ability to cross species barriers.

Purpose:

  • To investigate the potential risks associated with porcine endogenous retroviruses (PERVs) in the context of xenotransplantation.
  • To highlight the interspecific transmission capability of PERVs, particularly their in vitro expression in human cells.
  • To emphasize the need for monitoring recipients in xenotransplantation due to potential PERV adaptation.

Summary:

  • PERVs are endogenous retroviruses found in pigs, capable of interspecific transmission.

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Related Experiment Videos

Last Updated: Jun 16, 2026

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model
07:34

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model

Published on: September 22, 2020

Characterization of Blood Outgrowth Endothelial Cells (BOEC) from Porcine Peripheral Blood
08:02

Characterization of Blood Outgrowth Endothelial Cells (BOEC) from Porcine Peripheral Blood

Published on: January 6, 2022

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

  • While PERVs can infect human cells in vitro, in vivo transmission has not been documented.
  • Xenotransplantation using porcine materials carries a risk of novel retroviral adaptation in humans via PERVs.

    • Impact:

    • Xenotransplantation using PERV-carrying animal products poses a risk of novel retroviral adaptation in humans.
    • Close monitoring of xenotransplantation recipients and their partners is crucial to mitigate PERV-related risks.
    • The study underscores the importance of understanding ERV transmission dynamics in interspecies transplantation.