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Transdermal histamine in multiple sclerosis, part two: a proposed theoretical basis for its use
G Gillson1, J V Wright, E DeLack
1Tahoma Clinic, 515 West Harrison, Kent, WA 98032. gillson@uswest.net
Summary
This study suggests impaired digestion in multiple sclerosis (MS) patients may reduce histamine synthesis, potentially worsening MS symptoms. Supplementing histamine may alleviate symptoms through various mechanisms.
Area of Science:
- Neuroscience
- Gastroenterology
- Immunology
Background:
- Multiple Sclerosis (MS) is a chronic neurological disease.
- Previous research explored transdermal histamine for MS symptom amelioration.
- Digestive and assimilation impairments are noted in MS patients.
Purpose of the Study:
- To investigate the association between digestive impairments and histamine synthesis in MS patients.
- To explore the potential role of impaired histamine synthesis in MS pathogenesis.
- To discuss how exogenous histamine administration might alleviate MS symptoms.
Main Methods:
- Preliminary findings from a small cohort of MS patients in a private clinic.
- Analysis of gastric acid production, protein hydrolysis, and plasma histidine levels.
- Review of potential mechanisms of action for histamine in MS.
Main Results:
- An association was found between impaired gastric acid production, protein hydrolysis, and subnormal plasma histidine levels in MS patients.
- Impaired digestion may hinder histamine synthesis in MS.
- Pathological parallels between the central nervous system (CNS) and enteric nervous system (ENS) in MS are suggested.
Conclusions:
- Impaired histamine synthesis could contribute to MS symptoms.
- Exogenous histamine may offer therapeutic benefits for MS by enhancing digestion, boosting cerebral histamine levels, improving nerve function, increasing blood flow, modulating immune responses, and promoting remyelination.
- Further research is warranted to explore the CNS-ENS connection in MS and the therapeutic potential of histamine.