Related Experiment Videos
Perioperative myocardial cell injury: the relationship between troponin T and cortisol
E Mahla1, K Tiesenhausen, P Rehak
1Department of Anaesthesiology and Intensive Care Medicine, Department of Surgery, and Department of Obstetrics and Gynecology, University of Graz, Graz, Austria. cardanaesth@kfunigraz.ac.at
Study Objective:
To investigate whether there is an association between Troponin T (TnT), reflecting myocardial cell injury, and cortisol, reflecting the degree of surgical trauma and associated stress, in light of our recent evaluation of TnT as a marker of perioperative myocardial cell injury.
Design:
Prospective, cohort study.
Patients:
70 patients (67.4 +/- 8.7 yrs) with definite or at-risk coronary artery disease (CAD) undergoing elective noncardiac surgery (vascular n = 38, abdominal n = 21, orthopedic n = 8) with general (n = 63) or regional (n = 4) anesthesia with postoperative on-demand analgesia.
Measurements And Main Results:
Morning blood samples for TnT (upper limit of normal: <0.2 ng/mL), CK-MB (reference range
Conclusions:
The significant relationship between a highly sensitive and specific marker of myocardial cell injury and a marker of stress suggests that cardiac-risk patients undergoing stressful surgical procedures might benefit from close perioperative TnT monitoring with early recognition of myocardial cell injury.