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Updated: Jul 31, 2026

Examination of Thymic Positive and Negative Selection by Flow Cytometry
Published on: October 8, 2012
Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40
L S Walker1, A Gulbranson-Judge, S Flynn
1MRC Centre for Immune Regulation, University of Birmingham, UK. walker@itsa.uesf.edu
Abstract:
Given the importance of responding to infections with the right defensive strategy, much interest has focused on cytokine differentiation in CD4+ T cells. However, relatively little is known of the logistics of T-cell help for B cells. Here, Lucy Walker and colleagues propose key roles for CD28 and OX40 in coordinating the selection, expansion and migration of CD4+ T cells to B-cell follicles.
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