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The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis
B H Toh1, J W Sentry, F Alderuccio
1Department of Pathology and Immunology, Monash University Medical School, Victoria, Australia. Ban-Hock.Toh@med.monash.edu.au
Immunology Today
|June 29, 2000
Abstract:
The gastric H+/K+ ATPase is the causative autoantigen recognized by CD4+ T cells that mediate autoimmune gastritis. Pathogenic CD4+ T cells are regulated by CD25+CD4+ T cells. Here, it is proposed that waves of activation and migration of antigen presenting cells and CD4+ T cells to and from the target organ and draining lymph node result in tissue damage.