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A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
Published on: April 13, 2010
[Procedure for bronchodynamic tests with inhaled allergens]
J J Sienra Monge1, B E del Río Navarro, M A Rosas Vargas
1Hospital Infantil de México Federico Gómez, México, DF. jjsienra@data.net.com
Insights
Pediatric asthma, a common chronic condition, involves airway hyperreactivity. Bronchodynamic testing with standardized allergens helps diagnose functional issues in children, ensuring patient safety with specialized personnel.
Area of Science:
- Pediatric Pulmonology
- Allergy and Immunology
Context:
- Asthma is a prevalent chronic respiratory illness in children.
- It is defined by airway hyperreactivity to various stimuli, including allergens and nonspecific agents like methacholine and histamine.
Purpose:
- To outline the diagnostic utility of bronchodynamic tests in pediatric asthma.
- To detail the methodology for performing allergen challenges to assess bronchial hyperresponsiveness.
Summary:
- Bronchodynamic tests, specifically allergen challenges, are crucial for diagnosing functional impairments in pediatric asthma.
- These tests involve administering standardized, high-quality antigenic extracts incrementally until a 15% or greater decrease in Forced Expiratory Volume in 1 second (FEV-1) is observed.
- Utilizing either open or closed circuits with a dosimeter, the initial allergen dose is lower than that eliciting a positive skin test.
Impact:
- Accurate diagnosis of functional deficits in pediatric asthma.
- Standardized testing protocols ensure reliable assessment of bronchial hyperresponsiveness.
- Emphasizes the critical need for specialized personnel and patient safety during these procedures.
Abstract:
The asthma is one of the most frequent chronic illnesses in the children. It is characterized by hyperreactivity from the air roads to inspecific stimuli (metacholin and histamin) and specific (allergens). The broncodynamics tests determines the broncolability asthmatic boy's and they help to settle down the I diagnose functional. They should be carried out with antigenic extracts of high quality, lyophilized watery and standardized; you can use an open or closed circuit and a dosimeter, the initial dose of the allergen it is lower than with the one that the positive cutaneous reactivity was obtained, carrying out successive increments until the VEF-1 descend 15% or more. The patient's security is fundamental, they should be carried out for specialized personnel.
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