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Markers of collagen metabolism and insulin-like growth factor binding protein-1 in term infants
T Hytinantti1, E M Rutanen, M Turpeinen
1Helsinki City Maternity Hospital, Helsinki, Finland.
Insights
Fetal collagen metabolism in term infants relates to maturity, not growth status. Insulin-like growth factor binding protein-1 (IGFBP-1) reflects intrauterine growth independently of gestational age.
Area of Science:
- Perinatal Medicine
- Biochemistry
- Endocrinology
Background:
- Fetal growth is influenced by various factors, including hormonal and metabolic pathways.
- Collagen metabolism and insulin-like growth factor binding protein-1 (IGFBP-1) are key regulators of fetal development.
Purpose of the Study:
- To investigate the relationship between fetal growth parameters and specific markers of collagen metabolism and IGFBP-1 in term infants.
Main Methods:
- Cord vein plasma was collected from 67 term infants categorized as appropriate for gestational age (AGA), large for gestational age (LGA), or small for gestational age (SGA).
- Analysis included markers of collagen type I (PICP, ICTP) and type III (PIIINP) metabolism, and IGFBP-1 levels.
Main Results:
- Gestational age showed negative correlations with PICP, ICTP, and PIIINP, indicating collagen metabolism is linked to maturity.
- IGFBP-1 levels correlated negatively with birth weight and relative birth weight, but not gestational age, suggesting it reflects growth status.
Conclusions:
- Collagen metabolism in the term fetus is primarily determined by gestational maturity.
- IGFBP-1 serves as an indicator of intrauterine growth, independent of fetal maturity.
Aim:
To study the relation between fetal growth and markers of collagen metabolism and insulin-like growth factor binding protein-1 (IGFBP-1) in term infants.
Methods:
Cord vein plasma was obtained from 67 term infants of gestational age 37.1-41.7 weeks (39 appropriate for gestational age (AGA), 11 large for gestational age (LGA; relative birth weight >/= 2.0 SD), and 17 small for gestational age (SGA; relative birth weight
Results:
Negative correlations existed between gestational age and PICP (r = -0.294, p = 0.0158), ICTP (r = -0.338, p = 0.0052), and PIIINP (r = -0.432, p = 0.0003). These correlations were also found in SGA infants (all p < 0.05). IGFBP-1 showed negative correlations with birth weight and relative birth weight (r = -0.644, p = 0.0001, and r = -0.693, p = 0.0001 respectively) but not with gestational age (p>0.05).
Conclusions:
In the term fetus, collagen metabolism is primarily dependent on maturity and not on intrauterine growth status, whereas IGFBP-1 reflects intrauterine growth independently of maturity.