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Related Experiment Videos

Ontogeny of thymus factor secretion.

M Dardenne, J F Bach

    Annales D'Immunologie
    |November 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Serum thymic factor (TF) levels were tracked during development. TF secretion begins in fetal mice around day 12-13 and reaches adult levels by birth.

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    Area of Science:

    • Immunology
    • Developmental Biology
    • Endocrinology

    Background:

    • The thymus plays a crucial role in T-cell maturation.
    • Circulating thymic factor (TF) is a hormone produced by the thymus.
    • Understanding TF ontogeny is vital for assessing immune development.

    Purpose of the Study:

    • To investigate the developmental profile of circulating thymic factor (TF).
    • To determine the onset and progression of TF secretion during fetal and neonatal life.

    Main Methods:

    • Utilized the 0-conversion assay to detect and quantify serum TF.
    • Evaluated TF levels in pregnant thymectomized mice and newborn mice.

    Main Results:

    • Circulating thymic factor (TF) secretion commences between days 12-13 of gestation.

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  • Serum TF levels in newborns approximate those found in adult mice.

    • Conclusions:

    • The thymus initiates TF production during mid-fetal development.
    • The fetal thymus is capable of producing sufficient TF to reach adult levels by birth, suggesting a significant role in early immune readiness.