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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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Systematic circular permutation of an entire protein reveals essential folding elements

M Iwakura1, T Nakamura, C Yamane

  • 1National Institute of Bioscience and Human Technology, 1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan. iwakura@nibh.go.jp

Nature Structural Biology
|July 6, 2000
PubMed
Summary

Researchers identified "folding elements" by breaking protein backbones, revealing key regions for protein folding. These elements are crucial for understanding protein stability and function.

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