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Camphor hepatotoxicity.

A Uc1, W P Bishop, K D Sanders

  • 1Department of Pediatrics, University of Iowa College of Medicine, Iowa City, USA.

Southern Medical Journal
|July 6, 2000
PubMed
Summary
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Dermal application of camphor-containing cold remedies caused liver damage (hepatotoxicity) in an infant. Symptoms resolved after discontinuing use, highlighting potential dangers of topical camphor products.

Area of Science:

  • Toxicology
  • Pediatrics
  • Dermatology

Background:

  • Camphor is a common ingredient in over-the-counter cold remedies.
  • Ingestion of camphor is known to cause severe liver and central nervous system injury.
  • Neurotoxicity has been documented following dermal exposure to camphor.

Observation:

  • A 2-month-old infant developed hepatotoxicity.
  • The infant's condition occurred after the dermal application of a camphor-containing cold remedy.
  • Liver function tests normalized upon cessation of the remedy's use.

Findings:

  • This case represents the first reported instance of hepatotoxicity resulting from the dermal application of camphor.
  • Dermal exposure to camphor can lead to liver injury, not just neurotoxicity.

Related Experiment Videos

  • The study highlights the potential risks associated with topical camphor-based treatments.

    • Implications:

    • Healthcare providers should be aware of the potential for camphor-induced hepatotoxicity via dermal application in infants.
    • The efficacy and safety of camphor in topical cold remedies warrant further investigation.
    • This case underscores the importance of scrutinizing the safety of commonly used over-the-counter pediatric preparations.