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Noncaseating granulomatous disease in common variable immunodeficiency
N Kanathur1, R P Byrd, C L Fields
1Department of Pulmonary Medicine, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, USA.
Southern Medical Journal
|July 6, 2000
Abstract:
Patients with common variable immunodeficiency (CVID) are occasionally recognized to have a concurrent noncaseating granulomatous disease. The granulomatous disease (GD) associated with CVID shares many clinical properties typical of sarcoidosis. Some investigators speculate that the GD-CVID is actually sarcoidosis that is expressed atypically because of the patient's immunodeficiency. Clinical differences, however, have led other investigators to speculate that the GD-CVID is a distinct "sarcoid-like" granulomatous process.