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Synthesis and antitumor activity of selected 7-alkylidene substituted cephems
G Veinberg1, M Vorona, I Shestakova
1Latvian Institute of Organic Synthesis, Riga, Latvia. veinberg@osi.lanet.lv
Bioorganic & Medicinal Chemistry
|July 6, 2000
Abstract:
Selected 7-alkylidene substituted cephems were synthesized and subjected to antitumor assay. The effect of substituents was examined to establish structure-activity relationships. It was found that the intensive intracellular generation of nitric oxide induced by tert-butyl 7-alkylidene cephalosporanate sulfones could be also regarded as an additional cytotoxic factor taking place both in vitro and in vivo experiments.