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Shorter survival of SDF1-3'A/3'A homozygotes linked to CD4+ T cell decrease in advanced human immunodeficiency virus
A Brambilla1, C Villa, G Rizzardi
1AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milan, Italy.
The Journal of Infectious Diseases
|July 7, 2000
Summary
The SDF-1 3'A genotype is linked to faster human immunodeficiency virus type 1 (HIV-1) disease progression, particularly after AIDS diagnosis or CD4+ T cell loss. This finding highlights the role of this genetic variation in advanced HIV-1 stages.
Area of Science:
- Genetics
- Immunology
- Virology
Background:
- The SDF-1 3'A allele is a polymorphism potentially affecting human immunodeficiency virus type 1 (HIV-1) disease progression.
- Understanding genetic factors influencing HIV-1 is crucial for predicting disease trajectory.
Purpose of the Study:
- To investigate the association between the SDF-1 genotype and HIV-1 disease progression in a cohort of infected individuals.
- To determine if the SDF-1 3'A/3'A genotype correlates with accelerated disease advancement.
Main Methods:
- Genotyping of the SDF-1 polymorphism was performed on 729 HIV-1-infected individuals from three distinct cohorts.
- Survival analysis was conducted based on AIDS diagnosis (1993 definition) and CD4+ T cell counts (<200 cells/µL).
Main Results:
- A statistically nonsignificant association was found between the SDF1-3'A/3'A genotype and accelerated progression among seroconverters.
- A significant correlation was observed between the SDF1-3'A/3'A genotype and decreased survival post-AIDS diagnosis (HR=2.16, P=.0047) and CD4+ T cell count <200 (HR=3.43, P=.0001).
- No survival difference was noted after diagnosis using the older AIDS-'87 criteria.
Conclusions:
- The SDF1-3'A/3'A genotype is associated with accelerated progression of late-stage HIV-1 disease.
- The accelerated progression appears primarily driven by the loss of CD4+ T lymphocytes in individuals with the SDF1-3'A/3'A genotype.