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[Anaphylactic shock after diclofenac sodium (Voltaren)]
1Division of Obstetrics and Gynecology, Soroka University Medical Center, Beer Sheba.
Harefuah
|July 7, 2000
Summary
Anaphylaxis from diclofenac sodium (Voltaren) is rare. This case report details a severe, life-threatening reaction including angioedema and shock in a patient post-cesarean section.
Area of Science:
- Clinical Medicine
- Pharmacology
- Allergy and Immunology
Background:
- Diclofenac sodium is a common nonsteroidal anti-inflammatory drug (NSAID) used for pain relief.
- Anaphylaxis, a severe allergic reaction, is an uncommon but serious adverse effect of NSAIDs.
- Postoperative pain management often involves NSAIDs like diclofenac sodium.
Observation:
- A 39-year-old woman experienced severe angioedema and hemodynamic shock.
- The reaction occurred 10 minutes after receiving a diclofenac sodium suppository for analgesia.
- This event happened 6 hours after a cesarean section, with no prior adverse reactions to diclofenac.
Findings:
- The patient presented with an acute, multisystemic, life-threatening reaction to diclofenac sodium.
- This case highlights a rare instance of severe anaphylaxis to diclofenac sodium.
- Previous uneventful exposure to diclofenac did not preclude a severe reaction upon subsequent administration.
Implications:
- Clinicians should be aware of the potential for rare but severe anaphylactic reactions to diclofenac sodium, even after prior tolerance.
- Prompt recognition and management of anaphylaxis are critical in the postoperative setting.
- Further investigation into risk factors for NSAID-induced anaphylaxis may be warranted.