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Astroblastoma: clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridization
D J Brat1, Y Hirose, K J Cohen
1Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA. dbrat@emory.edu
Brain Pathology (Zurich, Switzerland)
|July 8, 2000
Summary
Astroblastomas, rare brain tumors, show distinct clinical and histopathologic features. Genetic analysis reveals chromosomal alterations, suggesting a unique cytogenetic profile for these tumors.
Area of Science:
- Neuro-oncology
- Cancer Genetics
- Pathology
Background:
- Astroblastomas are rare brain tumors with debated classification and histogenesis.
- Recent diagnostic criteria lack widespread acceptance.
- Understanding their unique characteristics is crucial for accurate diagnosis and treatment.
Purpose of the Study:
- To detail the clinical, radiographic, and histopathologic features of 20 astroblastomas.
- To investigate chromosomal alterations in seven astroblastomas using comparative genomic hybridization (CGH).
- To explore the potential for a characteristic cytogenetic profile in astroblastomas.
Main Methods:
- Retrospective analysis of clinical, radiographic, and histopathologic data from 20 patients.
- Comparative genomic hybridization (CGH) to detect chromosomal alterations in seven tumors.
- Classification into "well differentiated" and "malignant" based on defined criteria.
Main Results:
- Astroblastomas typically present as peripheral cerebral masses in children and young adults.
- Histopathology shows astroblastic pseudorosettes, hyalinization, and pushing borders.
- Frequent CGH findings include gains of 20q and chromosome 19.
- Malignant astroblastomas showed higher recurrence rates compared to well-differentiated ones.
Conclusions:
- Astroblastomas possess distinct clinical, radiographic, and histopathologic features.
- Specific chromosomal alterations (20q gain, 19 gain) may define a unique cytogenetic profile.
- These findings differentiate astroblastomas from ependymomas and astrocytic neoplasms.