Animal models for the study of milk secretion

Milk secretion is regulated by a complex interaction of galactopoietic hormones which is not yet fully understood. Recent studies have demonstrated that this systemic control is modulated within the mammary gland by local mechanisms responsive to the frequency and completeness of milk removal. New insights into the endocrine and local (paracrine and autocrine) regulation of milk secretion have come from the adaptation of traditional endocrinological techniques to take advantage of new molecular tools, and from technical advances in other fields. This paper reviews recently developed animal models for the study of milk secretion and describes their application to provide new information into the roles of two key galactopoietic hormones, growth hormone and prolactin, and the modulation of their actions by local, intramammary mechanisms.