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Related Experiment Videos

The prolactin/growth hormone receptor family: structure/function relationships.

V Goffin1, P A Kelly

  • 1INSERM Unit 344, Faculté de Médecine Necker, Paris, France.

Journal of Mammary Gland Biology and Neoplasia
|January 1, 1997
PubMed
Summary

Prolactin (PRL) and growth hormone (GH) receptors activate signaling pathways through ligand-induced homodimerization. This review explores receptor activation mechanisms and associated signaling molecules, including the JAK/Stat pathway.

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Area of Science:

  • Endocrinology
  • Molecular Cell Biology
  • Signal Transduction

Background:

  • Prolactin (PRL) and growth hormone (GH) receptors belong to the cytokine receptor superfamily.
  • Activation occurs via ligand-induced homodimerization, a mechanism exploited for antagonist development.

Purpose of the Study:

  • To review the mechanisms of PRL and GH receptor activation.
  • To discuss the involvement of associated kinases and signal transduction pathways.
  • To correlate receptor features with transducer molecule interactions and biological outcomes.

Main Methods:

  • Literature review focusing on PRL and GH receptor activation.
  • Analysis of signaling pathways, particularly the JAK/Stat pathway.
  • Correlation of receptor structure-function relationships with signaling molecule involvement.

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Main Results:

  • Receptor activation involves ligand binding and subsequent homodimerization.
  • Non-kinase receptors require associated kinases (e.g., JAK, Src) for signal transduction.
  • The JAK/Stat pathway is a primary route for signal transduction.

Conclusions:

  • Understanding receptor homodimerization and associated signaling molecules is crucial.
  • Cytoplasmic features of receptors influence transducer association and biological activity.
  • This knowledge aids in developing targeted hormone antagonists and understanding receptor function.