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[Antiarrhythmic effects of verapamil]
Archivos Del Instituto De Cardiologia De Mexico
|May 1, 1976
Summary
Verapamil effectively suppressed supraventricular tachycardias and decreased ventricular rates in atrial fibrillation and flutter. It also converted some ventricular tachycardias to sinus rhythm, showing its utility in managing arrhythmias.
Area of Science:
- Cardiology
- Clinical Pharmacology
Context:
- Supraventricular and ventricular tachycardias pose significant clinical challenges.
- Pharmacological interventions are crucial for managing cardiac arrhythmias.
Purpose:
- To evaluate the efficacy of intravenous verapamil in treating various supraventricular and ventricular tachycardias.
- To assess the electrophysiological effects of verapamil on cardiac conduction.
Summary:
- Intravenous verapamil (0.10–0.15 mg/kg) was administered during 50 episodes of tachycardia in 44 patients.
- Verapamil successfully restored sinus rhythm in 81% of PSVT cases and reduced ventricular response in atrial fibrillation and flutter.
- It also converted some ventricular tachycardias to sinus rhythm, with effects appearing within 2–4 minutes post-injection.
Impact:
- Verapamil is a valuable therapeutic option for suppressing PSVT and controlling ventricular rates in atrial fibrillation and flutter.
- The drug demonstrates utility in converting certain ventricular tachycardias to sinus rhythm.
- Caution is advised in digitalized patients and those with S-A node dysfunction.