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Auditory involvement in thalassemia major.

S De Virgiliis, F Argiolu, G Sanna

    Acta Haematologica
    |January 1, 1979
    PubMed
    Summary
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    Children with beta-thalassemia may experience hearing loss. Higher ferritin levels in these patients suggest iron overload could damage auditory function, particularly high frequencies.

    Area of Science:

    • Pediatric Hematology
    • Otolaryngology
    • Auditory Science

    Background:

    • Homozygous beta0-thalassemia requires management with blood transfusions.
    • Iron overload is a common complication of thalassemia treatment.
    • Auditory function can be affected by chronic illnesses and their treatments.

    Purpose of the Study:

    • To investigate auditory function in children with homozygous beta0-thalassemia.
    • To explore the relationship between iron overload and hearing impairment in this population.
    • To identify potential causes of auditory dysfunction in beta-thalassemia patients.

    Main Methods:

    • Auditory function assessment in 75 children with beta0-thalassemia and 75 controls.
    • Evaluation of hearing impairment types (conductive and sensorineural).

    Related Experiment Videos

  • Measurement of ferritin levels in a subgroup of patients with and without hearing loss.

    • Main Results:

    • 12 patients had mild conductive hearing impairment (bony/adenoid hypertrophy).
    • 43 patients exhibited moderate sensorineural hearing loss (high frequencies, recruitment).
    • Significantly higher mean ferritin levels were found in patients with sensorineural hearing loss compared to those without.

    Conclusions:

    • Iron overload may contribute to sensorineural hearing loss in beta-thalassemia patients.
    • High ferritin levels correlate with auditory damage, especially in high frequencies.
    • Other factors like intermittent hypoxia and bony hypertrophy may also play a role in auditory impairment.