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Updated: Jul 13, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
Published on: January 16, 2016
Kinetic aspects of nonlinear effects in asymmetric catalysis
1Department of Chemistry, University of Hull, Hull HU6 7RX, United Kingdom. D.G.Blackmond@chem.hull.ac.uk
Abstract:
Probing catalyst systems for a nonlinear relationship between product enantioselectivity and catalyst enantiopurity is now commonly being used as a mechanistic tool. We show that in some cases striking consequences for reaction rate can ensue for reactions carried out using non-enantiopure catalysts. We also demonstrate how consideration of the kinetic behavior may serve to enhance the use of nonlinear effects as a diagnostic tool for identifying active catalytic species and for providing mechanistic insight. Kinetic information may also help in the development of efficient synthetic strategies using non-enantiopure systems.
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