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A concise synthesis of topsentin A and nortopsentins B and D
F Y Miyake1, K Yakushijin, D A Horne
1Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, USA.
Organic Letters
|July 13, 2000
Abstract:
[reaction: see text] A concise synthesis of topsentin A (R(1) = R(2) = H) and nortopsentins B (R(1) = Br, R(2) = H) and D (R(1) = R(2) = H) is described from oxotryptamine 5 via reduction of acyl cyanide 4. Regiospecific bromination of 3-cyanoindole afforded 6-bromo-3-cyanoindole (10) as the major product.