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Early evolution of cytochrome bc complexes.

M Schütz1, M Brugna, E Lebrun

  • 1Laboratoire de Bioénergétique et Ingénierie des Protéines (UPR 9036, France.

Journal of Molecular Biology
|July 13, 2000
PubMed
Summary

Researchers analyzed cytochrome bc complexes across diverse bacteria and archaea, revealing evolutionary insights. They identified a lateral gene transfer event and proposed a minimal functional core for this essential enzyme.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Cytochrome bc complexes are crucial components of electron transport chains in diverse organisms.
  • Understanding their structure, function, and evolution is key to comprehending cellular energy production.

Purpose of the Study:

  • To analyze the primary structures, functional characteristics, and phylogenetic relationships of cytochrome bc complex subunits.
  • To investigate evolutionary patterns, including gene transfer events and the core components of the ancestral enzyme.

Main Methods:

  • Phylogenetic analysis of cytochrome bc complex subunits from bacterial and archaeal species.
  • Comparison of obtained phylogenies with small subunit ribosomal RNA (rRNA) trees.
  • Analysis of key phylogenetic markers and enzyme structures.

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Main Results:

  • A single instance of lateral gene transfer was identified, involving an epsilon-proteobacterial cytochrome bc(1) complex.
  • Phylogenetic analyses largely aligned with small subunit rRNA trees, with some localized modifications proposed.
  • The study defined the minimal functional and evolutionary core of the cytochrome bc enzyme.

Conclusions:

  • The ancestral cytochrome bc enzyme likely assembled from subunits with pre-existing roles in other electron transfer chains.
  • The study provides a refined understanding of cytochrome bc complex evolution and its core components.
  • Phylogenetic markers offer insights into the evolutionary history and structural variations of these complexes.